A multi-functional nanoplatform for efficacy tumor theranostic applications
Jinjin Shi;Hongling Zhang;Zhaoyang Chen;Lihua Xu;Zhenzhong Zhang;School of Pharmaceutical Sciences, Zhengzhou University;
Nanomaterials with multiple functions have become more and more popular in the domain of cancer research. MoS_2 has a great potential in photothermal therapy, X-ray/CT imaging and drug delivery. In this study, a water soluble MoS_2 nanosystem(MoS_2-PEG) was synthesized and explored in drug delivery, photothermal therapy(PTT) and X-ray imaging.Doxorubicin(DOX) was loaded onto MoS_2-PEG with a high drug loading efficiency(～69%)and obtained a multifunctional drug delivery system(MoS_2-PEG/DOX). As the drug delivery, MoS_2-PEG/DOX could efficiently cross the cell membranes, and escape from the endosome via NIR light irradiation, lead to more apoptosis in MCF-7 cells, and afford higher antitumor efficacy without obvious toxic effects to normal organs owing to its prolonged blood circulation and 11.6-fold higher DTX uptake of tumor than DOX. Besides, MoS_2-PEG/DOX not only served as a drug delivery system, but also as a powerful PTT agent for thermal ablation of tumor and a strong X-ray contrast agent for tumor diagnosis. In the in vitro and in vivo studies, MoS_2-PEG/DOX exhibited excellent tumor-targeting efficacy, outstanding synergistic anti-cancer effect of photothermal and chemotherapy and X-ray imaging property,demonstrating that MoS_2-PEG/DOX had a great potential for simultaneous diagnosis and photothermal-chemotherapy in cancer treatment.