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    《Chinese Journal of Critical Care Medicine》 2019-02
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    The advances of fibrinolytic abnormalities in severe trauma patients

    Xu Wen-xin;Feng Qi-ming;Department of Emergency Medicine,Shanghai Jiao Tong University Affiliated Sixth People's Hospital;  
    Despite a profound up-regulation in procoagulant mechanisms, at least one-quarter of trauma patients present with trauma-induced coagulopathy. These patients usually have post injury fibrinolytic abnormalities, which is associated with an increase in mortality and worse outcomes.Fibrinolytic abnormalities include fibrinolysis shutdown and hyperfibrinolysis. The former represents a deficiency of clot degradation and increased risk of thrombosis; the later appears primarily as an excess in clot degradation. Except conventional coagulation test, the diagnosis of fibrinolytic abnormalities mainly depends on viscoelastic hemostatic assay. This review covers the most recent evidence and advances in fibrinolytic abnormalities, which provides a new idea on the diagnosis and treatment for severe trauma patients with it.
    【CateGory Index】: R641
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