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    Effect of microecologics on the treatment of newly diagnosed systemic lupus erythematosus

    Fu Bingbing;Yue Caifang;Xuan Chunyan;Zou Xiaojun;Sun Xueqian;Sun Xiaopeng;Department of Rheumatology,the First Affiliated Hospital of Jiamusi University;  
    Objective To explore the effect of microecologics on treatment of newly diagnosed systemic lupus erythematosus(SLE).Methods Eighty patients with newly diagnosed SLE were randomly divided into control group(40 cases)and observation group(40 cases).Patients in two groups were all given standardized treatment of SLE,and patients in observation group were supplemented with bifidobacterium bifidum triple live bacteria tablets.SLE disease activity index(SLEDAI)score was used to assess the extent of disease activity of newly diagnosed SLE patients.Blood routine,erythrocyte sedimentation rate(ESR),IgA,IgG,complement C3,C4,ALT,AST,serum creatinine(Scr),urea nitrogen(BUN),24 h urine protein and fecal microflora abnormal rate were measured before treatment and 12 weeks after treatment.Results There were no significant differences of all indexes between the two groups before treament(P0.05).ESR,IgA,IgG,ALT,AST,Scr and BUN levels after treatment in two groups were all lower than those in the same group before treatment,complement C3 and C4 levels were higher than those in the same group before treatment,and fecal microflora abnormal rate after treatment was lower than that before treatment in observation group(P0.05).There were no significant differences of WBC count,Hb,PLT count,fecal microflora abnormal rate before and after treatment in control group and WBC count,Hb,PLT count before and after treatment in observation group(P0.05).IgA,IgG,AST level,fecal microflora abnormal rate,SLEDAI score and 24 h urine protein were lower in observation group than those in control group after treatment, and complement C3 level was higher than that in control group(P0.05).Conclusion After intervention of microecologics,the inflammation and immune response of newly diagnosed SLE patients are inhibited,urinary protein is reduced,and the digestive system symptoms are less.Liver and kidney adverse reactions of microecologics are small which shows microecologics is safe and effective for newly diagnosed.
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