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    Change and correlation of bone mineral density in different parts of medium-elderly men with nonalcoholic fatty liver disease

    Zhou Xiaoli;Wang Yan;Lei Hong;Department of Endocrine,Cardiovascular and Cerebrovascular Hospital of General Hospital of NingXia Medical University;  
    Objective To investigate the change and correlation of bone mineral density(BMD)in different age and different parts of medium-elderly men with nonalcoholic fatty liver disease.Methods A total 475 male patients with NAFLD were divided into 3 groups according the age:50-59 year-old,60-69 year-old and above 70 year-old group.Clinical data,BMD and the incidence rate of osteoporosis in different parts between 3 groups were compared.Pearson correlation analysis were used to evaluate the related factors of osteoporosis in different sites and linear regression analysis were used to explore the risk factors of BMD in different parts.Results As the patients grew older,BMD decreased and the incidence of osteoporosis increased.In 50-59 year-old group,BMD in lumbar was higher than that in 1/3 of the distal radius and femoral neck and the incidence of osteoporosis in 1/3 of the distal radius was higher than that in femoral and lumbar(P0.05).In 60-69 year-old group,BMD in femoral neck and lumbar was higher than that in 1/3 of the distal radius(P0.05).There were no statistical difference in BMD between 1/3 of the distal radius,femoral neck and lumbar in above 70 year-old group.Age and 25(OH)D deficiency were common risk factors for BMD loss in lumbar,femoral neck and 1/3 of the distal radius.However,BMI and blood calcium had protective effects on bone mineral density in lumbar,but had no protective effects in femoral neck and radius.Fasting plasma glucose(FPG)and blood phosphor were risk factors for BMD loss in radius.Conclusion As the patients grow older,the BMD decreased and the incidence of osteoporosis increased.The BMD in radius should be examined to reduce the missed diagnosis of osteoporosis.BMI had protective effect on BMD in lumbar but no effect in radius and femoral neck.
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